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WHY IT’S IMPORTANT TO TALK ABOUT YOUR RESEARCH WITH YOUR FAMILY

12/20/2019

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I have a large family: 4 brothers and sisters, 4 sibling-in-laws, 11 nieces and nephews, and a whole bunch of aunts, uncles, cousins, and “cousins” (relatives with an ambiguous blood line so you just call them “cousin”). When I attend family gatherings, I get a lot of questions. Overtime I have developed vague, rehearsed responses for when I am asked about my PhD at family events:
 
Relative: How is school?
Me: It’s going well, I have no more classes. I am just working in a lab now.
 
Relative: How much longer do you have, a year or so?
Me: Probably three, but it could be four or five.
 
Relative:
Oh! And how is research going?
Me: It’s going. Progress is slow but that’s how science works.
 
Relative: What exactly are you researching?
Me: I study cancer. (Usually at this point the relative is satisfied and I move on to another conversation).
 
Recently, my perspective has changed on how I should communicate science with my family. A couple of weeks ago I had lunch with my best PhD-friend, Matty, and his parents. Matty’s parents have master’s degrees in computer science and biology. They are very invested in Matty’s research and it is remarkable how well they empathize with Matty’s (and my) PhD journey. While Matty and I were speaking about some STEM education work, Matty’s mother said something remarkable, “Technically as researchers who are funded by the government, you are public servants. Your work is given to you by taxpayers, with confidence that your research and knowledge will benefit society. It’s important that you share with others what you are doing.”
 
I was awed by this idea. When working in a lab it’s easy to exist in a bubble. My PI, lab mates, and myself rarely discuss research  from the perspective of increasing human intelligence. Rather, it’s more like: “What can we publish?” “When can we publish it?” “How many publications should I have before I graduate?”
 
The idea that I am a public servant has grounded me and has given me purpose. I am not doing research solely to advance my career or to pad my CV. I am doing research to further the collective human knowledge, and I should educate those around me who are interested in my field.
 
When I go home for the holidays this year, I intend to share my PhD and research experiences with my family.  However, there is a problem. Speaking with the average person about science is not easy, but it is a valuable skill to have. Here are some tips for speaking to friends and family about your research:
  1. Speak in short sentences. No one wants a lecture. Shorter sentences allow for your family members to ask questions and stay engaged.
  2. Easy on the jargon…. even if it means sacrificing some accuracy. I have family members who don’t know what RNA and proteins are (they hear protein and think muscle tissue). I use the word “molecules” instead.
  3. Know your audience. I have cousins who are nurses and physical therapists, I can go into more detail about my research with them.  
  4. If they aren’t interested, don’t push them. There is no reason to perpetuate disinterest in the sciences by overwhelming your audience with information.  ​
  5. Don't be afraid to say "I don't know." When people find out you are a scientist, you may get bombarded with questions outside of your field. Remember to stick with what you know, it's better to admit ignorance than spread misinformation.  


Author

Kerry McPherson, PhD Candidate studying biomedical sciences. Researches proteins implicated in acquired chemoresistance in cancer. Passionate about STEM education outreach, climate change policy advocacy, and inclusivity.

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BAD BATCH, MEDICAL REPORTING AT ITS FINEST

12/16/2019

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IMAGE CREDIT: WONDERY. 


Earlier this year I was obsessed with the story of Elizabeth Holmes, the entrepreneur who built a medical device company valued at $4.5 billion. Her company sought to revolutionize the blood test industry by making devices which could run numerous blood tests on only a drop of blood. The problem? Her devices did not work, and the data she presented to investors were fraudulent. She knowingly marketed a severely flawed product that could not produce accurate nor reproducible results. And, thanks to the marvelous reporting of John Carreyou, her fraud was ousted. Holmes's company crumbled, and in the matter of months her net worth plummeted from $4.5 billion to $0. Three personality traits of Elizabeth struck me as the root of her malice:

  1. Pride – Holmes could not accept blame, nor could she take inconvenient advice from experts.
  2. Impatience – Holmes marketed and sold her product well before it was ready for use.
  3. Lack of science knowledge  - she dropped out after sophomore year from Stanford and did not pursue much self-education thereafter.
 
To reiterate, I was obsessed with this story. I listened to the podcast (The Dropout), read the book (Bad Blood by John Carreyou), and watched the HBO documentary (The Inventor). And of course, I’ll be watching the new Hulu series, The Dropout, starring Kate McKinnon when it airs.
 
This past week I had the pleasure of learning about another biotechnology injustice by listening to Wondery’s podcast, Bad Batch.  Laura Beil returns for a second medical mystery podcast after her success with Wondery’s Dr. Death (unequivocally my favorite podcast of all time). Bad Batch begins with the investigation of three patients who receive stem cell treatments, only to be hospitalized in the days following the treatment. The patients complained of fevers, vomiting, spasms, and immobility to name a few symptoms. And from this event, Laura Beil begins an investigation that goes on to question the validity of the stem cell industry.
 
                                      ****Spoilers ahead…if I’ve sold you on Bad Batch, go and listen.****
 
 The three hospitalized patients had been injected with umbilical cord stem cells contaminated with E. coli. The cells were manufactured by a hurried start-up, Genetech, and distributed by Liveyon.  Liveyon scrambled to save its image from the incident. The company blamed the doctors, stating that their product was free of contamination at the time of distribution. “We’re a victim as much as the patients who were infected.” Said the CEO of Liveyon, John Kosolcharoen.
 
As Laura Beil digs on, we find Kosolcharoen has a shady business reputation. Actually, he's pretty much a scum bag.  When he started Liveyon he had just been indicted for receiving illegal kickbacks for a $15,000/tube pain cream. But start another medical venture he did, after all, he just wants to help people…
 
As you may have guessed, the contaminated stem cells were not an isolated event. A doctor in Maine, John Herzog, tested the product on himself and  immediately experienced severe pain. He went to the ER and discovered that he was infected with E.coli and an Enterobacter. He agreed to have a vial of stem cells he had purchased from Liveyon tested. The results? No detectable live stem cells were found in the vial.
 
Even after the incident in Texas with the three injured patients, Liveyon thrived. They marketed their product in “educational” seminars where salespeople made ridiculous claims that stem cells were a cure-all for Parkinson’s, arthritis, back pain, and even autism. That’s right, a salesman apocryphally claimed that an autistic child who could not show affection was able to hug his mother after being treated with Liveyon’s stem cells.
 
By the end of the podcast Liveyon is still a success. Although it seems that Kosolcharoen is aware that the US Food and Drug Administration has a target on him. So… he is expanding overseas.
 
Throughout the podcast, I could not help but draw parallels between Kosolcharoen and Elizabeth Holmes. Similar to Holmes, Kosolcharoen was proud, impatient and lacked education in science. The growth of his company was not for the advancement of medicine and the well-being of others, but for the swelling of his own hubris and financial advancement. He refused to wait for proper research of their product before marketing and selling to the public. And, Kosolcharoen inherently did not understand the science of the stem cells he was selling. He is educated mostly by Google and Wikipedia.
 
Ok fellow scientists, let’s take a step back for some introspection.  Search yourself for signs of pride, impatience, and deficiency of knowledge within your research. I know I have been guilty of all three at one point during my Ph.D. In the future, I will improve on these issues to make sure that I am performing ethical, careful, and unbiased work.
 
I’d like to thank Laura Beil and Wondery for this marvelous piece of medical journalism. Since the podcast, Liveyon has shut down sales of their stem cells.
 
Still interested? even though you read the spoilers? Listen to Bad Batch. If you like this genre, I full heartedly recommend Dr. Death as well.


Author

Kerry McPherson, PhD Candidate studying biomedical sciences. Researches proteins implicated in acquired chemoresistance in cancer. Passionate about STEM education outreach, climate change policy advocacy, and inclusivity.

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